Kidney Single-Cell Atlas Reveals Myeloid Heterogeneity in Progression and Regression of Kidney Disease
نویسندگان
چکیده
منابع مشابه
Progression versus regression of chronic kidney disease.
Chronic kidney disease (CKD) is a major cause of morbidity and mortality worldwide, and is characterized by relentless progressive scarring of renal parenchyma that ultimately results in end-stage renal disease with the need for dialysis or transplantation. Scarring is, however, not an inherently irreversible process, as it may be modulated in, for example, skin, heart and large arteries. Howev...
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The rise in the prevalence of chronic kidney disease (CKD) and an increase in the prevalence of obesity in parallel in the recent years is a great concern. CKD increases the rate of cardiovascular disease (CVD) and development of end-stage renal disease, and leads to premature death. Although no direct causality link between obesity and CKD can yet be established, this appears highly probable. ...
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W hether we like it or not, nephrologists around the world have been called to action. Our mission is to attenuate the growth of chronic kidney disease (CKD). Several conditions will need to gel for us to succeed. Although we now have a better understanding of its alarming incidence and prevalence within populations, however we choose to define it, better methods are needed to identify at risk ...
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It has been known for decades that increased dietary intake of salt (NaCl) shortens the life span of rats in a dose-dependent fashion. This review focuses specifically on the recently described biological effect and consequences of increased salt ingestion on the endothelium through a mechanism that is independent of blood pressure. Changes in salt intake are recognized by endothelial cells in ...
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Arterial stiffness can nowadays be measured easily and noninvasively around the globe. Although well established as an independent predictor of cardiovascular events, less is known about the role of arterial stiffness in the progressive loss of kidney function once chronic kidney disease (CKD) is established. In addition to measures of arterial stiffness, a number of devices now noninvasively r...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2020
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.2020060806